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The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity
Semaglutide 2.4 mg weekly may reduce energy intake, appetite, eating control, and stomach emptying in adults with obesity
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Abstract
Ad libitum energy intake was 35% lower with semaglutide 2.4 mg compared to placebo.
- The area under the concentration-time curve for paracetamol increased by 8% with semaglutide versus placebo at week 20.
- No significant effect on gastric emptying was observed when corrected for body weight.
- Semaglutide reduced hunger and increased feelings of fullness and satiety compared to placebo.
- Participants reported better control of eating and fewer food cravings with semaglutide.
- Body weight decreased by 9.9% with semaglutide, while the placebo group experienced a reduction of only 0.4%.
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Key numbers
940 kJ
Decrease in Energy Intake
Estimated treatment difference in ad libitum energy intake between groups at week 20.
9.9%
Weight Loss
Percentage reduction in body weight from baseline to week 20 with semaglutide.
13 mm
Appetite Suppression Score Increase
Estimated treatment difference in overall appetite suppression score after breakfast.