Semaglutide changes behavior and activity in the brain's reward system in healthy mice

Daily administration of semaglutide (0.1 mg/kg) in healthy mice alters behavior related to stress and reward pursuit.

• Semaglutide is associated with changes in behavior in healthy subjects, particularly in stress and reward-related tests.
• Acute administration of semaglutide alters oscillatory brain activity in the nucleus accumbens across delta, theta, and alpha frequency bands.
• These findings suggest that semaglutide affects both behavior and neural dynamics in non-diseased brains.

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