Semaglutide may influence decision-making between exploring and exploiting options in major depression

The effects of a GLP-1 receptor agonist, semaglutide, were examined on explore/exploit decision-making in patients with major depressive disorder (MDD).

• Explore/exploit decision-making is important for motivated behavior and is linked to cognitive and reward-related functions.
• These behaviors have associations with various neuropsychiatric conditions, including major depressive disorder.
• Metabolic mechanisms may influence the processes underlying explore/exploit decisions.
• The study utilized a four-armed restless bandit task to assess the effects of semaglutide on these behaviors.

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