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Semaglutide lowers body weight in rodents via distributed neural pathways
Semaglutide lowers body weight in rodents through multiple brain systems
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Abstract
Semaglutide induced weight loss and reduced food intake while maintaining energy expenditure.
- Weight loss may be linked to changes in food preference and intake mediated by GLP-1 receptors in the brain.
- Semaglutide accessed key brain regions involved in appetite regulation, including the brainstem and hypothalamus, without crossing the blood-brain barrier.
- Activation of c-Fos was observed in 10 brain areas, indicating diverse neural pathways may be involved in its effects on food intake.
- Upregulation of specific hormones and enzymes was noted in the area postrema following semaglutide treatment.
- The interaction of semaglutide with various GLP-1 receptor populations could influence neural pathways related to food intake and energy management.
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