Semaglutide lowers smell-driven movement and reproduction in roundworms

Wild-type C. elegans exposed to semaglutide (1 µM and 10 µM) showed significantly reduced chemotaxis.

• Semaglutide reduced the attraction of C. elegans to the odorant diacetyl.
• Egg-laying was decreased in C. elegans treated with semaglutide.
• Larval development was delayed at both concentrations of semaglutide tested.
• The findings indicate that semaglutide affects various behaviors and developmental processes in C. elegans.

Simplified