Semaglutide impacts skeletal muscle to a similar extent as caloric restriction in mice with diet‐induced obesity

Semaglutide treatment resulted in a greater weight loss than caloric restriction in mice, with significant impacts on body composition.

• Weight loss was greater with semaglutide than with matched caloric restriction, despite equal energy intake.
• Both semaglutide and caloric restriction led to a reduction in lean mass, including skeletal muscle.
• Muscle size and strength were comparable between mice treated with semaglutide and those on caloric restriction.
• Following the discontinuation of semaglutide and caloric restriction, lean and fat mass rebounded to baseline levels.
• Distinct molecular responses in muscle were observed between semaglutide treatment and caloric restriction.

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