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Semaglutide‐induced weight loss improves mitochondrial energy efficiency in skeletal muscle
Weight loss from semaglutide improves energy use in muscle mitochondria
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Abstract
Semaglutide treatment improved skeletal muscle oxidative phosphorylation efficiency, measured as ATP produced per oxygen consumed.
- Significant reductions in both fat and lean mass were observed with semaglutide treatment.
- Mitochondrial efficiency in muscle increased, indicating enhanced energy production capabilities.
- Changes in mitochondrial proteins related to complex III assembly were noted, although there were no substantial changes in overall subunit levels.
- The findings suggest a potential mechanism for weight regain after discontinuation of semaglutide treatment.
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Key numbers
23%
Weight Loss After 3 Weeks
Percentage reduction in body weight after treatment.
42%
Fat Mass Reduction After 3 Weeks
Percentage decrease in fat mass following treatment with .
10%
Lean Mass Reduction After 3 Weeks
Approximate percentage decrease in lean mass after 3 weeks of treatment.