Cureus

Link Between Semaglutide or Tirzepatide Treatment and Remaining Stomach Contents That May Risk Upper Endoscopy

Updated

Abstract

Among 144 patients, 11 taking semaglutide or tirzepatide for over six months had residual gastric content during esophagogastroduodenoscopy.

  • A significant association was found between GLP-1 usage for more than six months and the presence of residual gastric content (p<0.001).
  • Of the 12 patients on long-term GLP-1 therapy, 91.7% exhibited residual gastric content.
  • No residual gastric content was observed in the 132 patients who did not meet the inclusion criteria.
  • A moderate positive association was noted between residual gastric content and age.
  • A weak negative association was identified between residual gastric content and body mass index (BMI).
  • There were no procedure-related complications, and all patients were discharged on the same day.

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Funding

Competing interests

Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
PubMed

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