Clinical obesityMar 11, 2023

Once-weekly semaglutide 2.4 mg and its impact on weight and quality of life in East Asian adults

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Apr 1, 2026

Abstract

In a trial with 401 participants, semaglutide 2.4 mg significantly improved weight-related quality of life scores compared to placebo.

Both semaglutide doses (2.4 mg and 1.7 mg) led to significant improvements in the Psychosocial and Total scores of weight-related quality of life.
Semaglutide 2.4 mg showed significant benefits in the Physical score compared to placebo.
Improvements in Physical Functioning were significantly observed with semaglutide 2.4 mg in the health-related quality of life assessment.
No significant benefits were found for other health-related quality of life domains with either semaglutide treatment compared to placebo.
Participants with higher baseline body mass index showed greater improvements in quality of life scores with semaglutide 2.4 mg.

Simplified

We assessed the effect of semaglutide 2.4 and 1.7 mg versus placebo on weight-related quality of life (WRQOL) and health-related quality of life (HRQOL) in the STEP 6 trial. Adults from East Asia (body mass index [BMI] ≥27.0 kg/mwith ≥2 weight-related comorbidities, or ≥35.0 kg/mwith ≥1 weight-related comorbidity) were randomized 4:1:2:1 to once-weekly subcutaneous semaglutide 2.4 mg or placebo, or semaglutide 1.7 mg or placebo, plus lifestyle intervention for 68 weeks. WRQOL and HRQOL were assessed from baseline to Week 68 using the Impact of Weight on Quality of Life-Lite Clinical Trials Version (IWQOL-Lite-CT) and the 36-Item-Short-Form-Survey-version-2.0 acute (SF-36v2), with changes in scores by categories of baseline BMI (</≥30 and ≥35 kg/m) also assessed. In total, 401 participants (mean body weight 87.5 kg, aged 51 years, BMI 31.9 kg/m, waist circumference 103.2 cm) were included. From baseline to Week 68, the IWQOL-Lite-CT Psychosocial and Total scores were significantly improved with semaglutide 2.4 and 1.7 mg versus placebo. For Physical score, effects were only in favour of semaglutide 2.4 mg versus placebo. In the SF-36v2, Physical Functioning was significantly improved with semaglutide 2.4 mg versus placebo, but no beneficial effects favouring either semaglutide treatment arms versus placebo were seen in the other SF-36v2 domains. Benefits favouring semaglutide 2.4 mg versus placebo were also observed in subgroups with higher BMIs for IWQOL-Lite-CT and SF-36v2 Physical Functioning scores. Treatment with semaglutide 2.4 mg improved aspects of WRQOL and HRQOL in people from East Asia with overweight/obesity. 2 2 2 2

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Once-weekly semaglutide 2.4 mg and its impact on weight and quality of life in East Asian adults

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