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Abstract
Cellular senescence involves a hypersecretory state known as the senescence-associated secretory phenotype (SASP).
- The SASP is characterized by the release of various signaling molecules that influence neighboring cells and tissues.
- It is associated with both beneficial and detrimental effects on health, depending on the context of its action.
- The composition and dynamics of the SASP can vary, indicating its heterogeneity in different biological settings.
- SASP may serve as a biomarker for aging and age-related diseases, providing insights into overall health span.
- Inhibiting the SASP could represent a potential therapeutic approach for treating cancer and other conditions linked to aging.
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