Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions

Cellular senescence is associated with irreversible growth arrest and diverse functional changes.

• Transient senescence may contribute to beneficial processes like tissue repair and tumor suppression.
• The accumulation of senescent cells is implicated in tissue dysfunction, chronic inflammation, and age-related diseases.
• The senescence-associated secretory phenotype (SASP) can have both pro-inflammatory and immunosuppressive effects, varying by cell type and context.
• Senotherapeutics include senolytics, which induce apoptosis of senescent cells, and senomorphics, which modulate harmful aspects of their phenotype.
• Major classes of senolytics include tyrosine kinase inhibitors and BCL-2 family inhibitors, while senomorphics encompass mTOR and JAK inhibitors.

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