Full text is available at the source.
Abstract
Single-cell analysis of the pancreas from 26 donors (ages 20-80) reveals two distinct populations of senescent cells.
- Senescent cells (SnCs) are identified as having either impaired or retained functional characteristics.
- One subpopulation of SnCs shows loss of β-cell identity and impaired insulin secretion, along with a proinflammatory response.
- The other subpopulation retains transcriptional identity and functional competence, exhibiting lower levels of inflammation.
- Increased immune cell infiltration is associated with the maladaptive SnC subpopulation.
- These findings highlight the heterogeneity of cellular senescence in the pancreas, which may inform future therapies for type 2 diabetes.
Simplified