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Abstract
Cellular senescence is associated with aging and age-related diseases, revealing unique transcriptomic programs in senescent cell subsets.
- Senescence is a state of permanent growth arrest following cell damage.
- Heterogeneity within senescent populations may play a crucial role in age-related pathologies.
- Specific surface proteins on senescent cells can be used to differentiate between subpopulations.
- Unique gene expression patterns are linked to certain surface protein markers in senescent cells.
- This methodology could be adapted to study other cell types with distinct transcriptomic profiles.
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