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Abstract
Cellular senescence is a key mechanism of aging, negatively affecting tissue and organ function.
- Senescent cells contribute significantly to aging through various detrimental effects on tissues.
- Key characteristics of senescent cells include genomic changes, cell cycle arrest, and dysfunction in lysosomes and mitochondria.
- The production of senescence-associated secretory phenotype (SASP) factors is linked to the negative impact of senescent cells.
- Current discussions focus on geroprotective therapy methods and emerging strategies for anti-aging treatments.
- A review of literature up to March 2025 highlights the importance of targeting senescent cells for potential therapeutic advancements.
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