Serotonergic Integration of Circadian Clock and Ultradian Sleep–Wake Cycles

Oct 19, 2012The Journal of neuroscience : the official journal of the Society for Neuroscience

How serotonin links the daily body clock with shorter sleep-wake cycles

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Abstract

Neuronal activity in the basal forebrain/preoptic area (BF/POA) exhibits a diurnal rhythm that can be disrupted by serotonin depletion.

  • The suprachiasmatic nucleus (SCN) generates a 24-hour rhythm of sleep and arousal.
  • Neuronal activity in the SCN shows robust circadian spiking, while activity in the BF/POA is influenced by sleep-wake states.
  • Acute serotonin depletion disrupts the diurnal rhythm in the BF/POA without affecting the SCN's circadian activity.
  • Blockade of serotonergic transmission in the BF/POA alone is enough to disrupt the diurnal sleep-wake rhythm in mice.
  • These findings suggest the serotonergic system may link circadian rhythms to ultradian sleep-wake cycles.

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