(TC) levels may influence all-cause mortality in very elderly individuals, with a 1.7-fold higher mortality rate observed in those with low TC compared to high TC.
In a study of 207 participants aged 85, 120 deaths were recorded over 10 years.
Participants with high TC (≥209 mg/dL) and intermediate TC (176-208 mg/dL) had longer survival rates than those with low TC (≤175 mg/dL).
Men with high TC survived longer than those with low TC, whereas no significant difference was found among women.
Total mortality in the low-TC group was 1.7 times greater than in the high-TC group after adjusting for various health factors.
Mortality risk decreased by 0.9% for each 1 mg/dL increase in serum TC and by 0.8% for each 1 mg/dL increase in LDL-cholesterol.
Simplified
Little is known about the association between (TC) and all-cause mortality in the elderly (especially the very elderly). Here we examined the association between TC and all-cause mortality in 207 very elderly (85-year-old) participants. In 2003, we performed a baseline laboratory blood examination, and blood pressure (BP) and body mass index (BMI) measurements, and lifestyle questionnaires were completed by the participants. The participants were followed for the subsequent 10 years. As of 2013, of the 207 participants in 2003, 70 participants had survived, 120 individuals had died, and 17 were lost to follow up. The TC values were divided into high-TC (≥209 mg/dL), intermediate-TC (176-208 mg/dL), and low-TC (≤175 mg/dL) categories. With the Kaplan-Meier method, we found that both the high-TC and intermediate-TC participants survived longer than the low-TC participants. The men with high TC survived longer than those with low TC, but no corresponding difference was found for the women. A multivariate Cox proportional hazards regression model, with adjustment for gender, smoking, alcohol intake, history of stroke or heart disease, serum albumin concentration, BMI, and systolic BP, revealed that the total mortality in the low-TC group was 1.7-fold higher than that in the high-TC group. Mortality, adjusted for the same factors, decreased 0.9% with each 1 mg/dL increase in the serum TC concentration and decreased 0.8% with each 1 mg/dL increase in the serum (low-density lipoprotein) LDL-cholesterol (LDL-C) concentration. Our results indicate an association between lower serum TC concentrations and increased all-cause mortality in a community-dwelling, very elderly population. Mortality decreased with the increases in both TC and LDL-C concentrations, after adjustment for various confounding factors. These findings suggest that low TC and low LDL-C may be independent predictors of high mortality in the very elderly.
Key numbers
1.7×
Increased Mortality Risk
Total mortality in the low- group compared to the high- group.
71.2 months
Mean Survival Time
Average survival time for participants with low concentrations.
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