Full text is available at the source.
Four new sesquiterpenes from the rhizomes ofCurcuma phaeocaulisand their iNOS inhibitory activities
Four new natural compounds from Curcuma phaeocaulis roots that may reduce inflammation enzyme activity
AI simplified
Abstract
Compound 3 inhibited nitric oxide production with an IC50 value of 6.05 ± 0.43 μM.
- Three new sesquiterpenes, phaeocaulisins K-M (1-3) and phagermadiol (4), were isolated from Curcuma phaeocaulis.
- Compound 1 is identified as the first norsesquiterpene with a tropone backbone.
- Compound 3 features a novel 1,2-dioxolane structure and is classified as a sesquiterpene alcohol.
- All isolated compounds were evaluated for their ability to inhibit nitric oxide production in macrophages.
- The biosynthetic pathway for compounds 3 and 4 in Curcuma phaeocaulis was proposed.
AI simplified