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Abstract
Psychedelics like psilocybin and LSD may exert different effects based on sex, influencing neurobiological and behavioral outcomes.
- Sex-dependent variability in the effects of psychedelics is evident across pharmacokinetics, physiology, and behavior.
- Notable differences in serotonergic and dopaminergic signaling patterns have been observed between males and females.
- Female rodents show distinct central amygdala reactivity to psilocin compared to males.
- Behavioral responses, such as head twitch and locomotor activity, often exhibit stronger effects in females.
- The phase of the ovarian cycle can further influence behavioral responses to psychedelics.
- Diverse therapeutic and adverse outcomes related to psychedelics have been found in disease model studies, suggesting sex differences in treatment responses.
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