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Abstract
Sex and endocrine state may modulate responses to classic serotonergic psychedelics through various serotonergic mechanisms.
- Classic psychedelics primarily act by activating the 5-HT2A receptor.
- Therapeutic effects of these compounds can vary significantly based on biological sex.
- Existing studies often overlook sex-by-treatment effects, limiting understanding of variability.
- Sex and endocrine state may influence serotonin clearance and signaling pathways.
- There is a need for more sex-informed research in both preclinical and clinical settings.
Simplified
Psychedelic Science