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Sex‐specific acceleration of Alzheimer's pathogenesis by chronic sleep‐deprivation
Chronic sleep loss may speed up Alzheimer's disease differently in men and women
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Abstract
Sleep-deprived mice exhibited increased stress and signs of accelerated Alzheimer's pathology.
- Chronic sleep disruption is associated with altered sleep-related behaviors in mice.
- Increased stress levels were observed in sleep-deprived mice.
- Mice showed sex-dependent neurodegeneration and protein accumulation following sleep loss.
- Changes in cellular processes related to waste removal and neuroinflammation were noted.
- Cognitive impairment correlated with the effects of chronic sleep disruption.
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Key numbers
0.0025
Increased Aβ Plaque Coverage
Significant increase in plaque coverage following sleep disruption.
0.0040
Corticosterone Elevation
Chronic sleep deprivation significantly elevated corticosterone levels.
0.0365
p62 Clustering Increase
Significant upregulation of p62 clusters in the hippocampus following sleep deprivation.