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Abstract
SHED-Exo effectively ameliorated bone loss in aged osteoporotic mice without causing organ toxicity.
- SHED-Exo are enriched in proteins associated with bone formation and the process of cleaning up damaged mitochondria.
- Treatment with SHED-Exo restored mitochondrial function and promoted the development of bone-forming cells in aging bone marrow stem cells.
- Activation of the cellular cleanup process, known as mitophagy, is linked to the therapeutic effects observed in senescent bone marrow stem cells.
- The findings suggest that SHED-Exo may serve as a promising therapeutic approach for age-related osteoporosis.
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