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Detecting aging cells individually and in their tissue location using DeepScence

Updated

Abstract

DeepScence can accurately identify senescent cells in single-cell and spatial transcriptomics data.

  • DeepScence utilizes a deep neural network to pinpoint senescent cells.
  • The method is based on a curated set of senescence-associated genes.
  • It outperforms existing techniques in identifying senescent cells across multiple data collection platforms.
  • Demonstrated effectiveness includes both in vitro and in vivo gene expression data.

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Full Text

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Funding

Competing interests

A.N. receives funding from Genentech, Genmab, MedImmune/AstraZeneca, and Seattle Genetics. A.N. is a consultant of Sanofi, Promega, and Leap Therapeutics.
PubMed

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