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SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation
SIRT1 controls the body’s daily clock by modifying the PER2 protein
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Abstract
SIRT1 is required for high-magnitude circadian transcription of several core clock genes.
- SIRT1 binds to the CLOCK-BMAL1 complex in a circadian pattern.
- This binding promotes the deacetylation and degradation of the PER2 protein.
- Core clock genes affected include Bmal1, Rorgamma, Per2, and Cry1.
- SIRT1's activity depends on NAD(+), suggesting a link between metabolism and circadian rhythms.
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