SIRT1 controls the body’s daily clock by modifying the PER2 protein

SIRT1 is required for high-magnitude circadian transcription of several core clock genes.

• SIRT1 binds to the CLOCK-BMAL1 complex in a circadian pattern.
• This binding promotes the deacetylation and degradation of the PER2 protein.
• Core clock genes affected include Bmal1, Rorgamma, Per2, and Cry1.
• SIRT1's activity depends on NAD(+), suggesting a link between metabolism and circadian rhythms.

Simplified