New Insights into Sirtuin Proteins in Lung Diseases

Sirtuins are implicated in the pathogenesis of pulmonary diseases through their roles in oxidative stress, metabolism, and inflammation.

• Sirtuins are NAD+-dependent enzymes that regulate various cellular processes, including mitochondrial function and cell survival.
• Dysregulated expression and activity of sirtuins are associated with chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer.
• Sirtuins may serve as diagnostic biomarkers and therapeutic targets in lung pathologies.
• Recent advances highlight the potential molecular mechanisms by which sirtuins influence lung disease progression.
• A comprehensive literature review was performed on the relationship between sirtuins and lung-related diseases.

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