Investigation of the relationships between sleep behaviors and risk of healthspan termination: a prospective cohort study based on 323,373 UK-Biobank participants

May 7, 2021Sleep & breathing = Schlaf & Atmung

How Sleep Habits Are Linked to Risk of Ending Healthy Life in Over 320,000 UK Adults

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Abstract

Participants with unhealthy sleep behaviors had a significantly higher risk of healthspan termination.

Experiencing sleeplessness or insomnia usually is associated with a 5% increased risk of healthspan termination.
Regular napping is linked to a 22% increased risk of healthspan termination.
Excessive daytime sleepiness correlates with a 25% increased risk of healthspan termination.
Difficulty getting up from bed is associated with an 8% increased risk of healthspan termination.
Approximately 7% of healthspan terminations could potentially be prevented if all participants practiced healthy sleep behaviors.

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OBJECTIVES: To examine the associations between four sleep behaviors and the risk of healthspan termination.

METHODS: This study included 323,373 participants, free of terminated healthspan at baseline, from the UK-Biobank (UKB). We applied multivariable-adjusted Cox regression models to estimate the risk of terminated healthspan based on four sleep behaviors (insomnia/sleeplessness, napping, daytime sleepiness, and difficulty getting up from bed), which were self-reported and measured on Likert scales from "usually" to "never/rarely" experiences. In this study, healthspan was defined based on eight events that are strongly associated with longevity (congestive heart failure, myocardial infarction, chronic obstructive pulmonary disease, stroke, dementia, diabetes, cancer, and death).

RESULTS: Participants who reported the following unhealthy sleep behaviors had a significantly higher risk of terminated healthspan: "usually experience sleeplessness/insomnia" (HR = 1.05, 95% CI: 1.03-1.07; P < 0.001); "usually nap" (HR = 1.22, 95% CI: 1.18-1.26; P < 0.01); "excessive daytime sleepiness" (HR = 1.25, 95% CI: 1.19-1.32; P < 0.001); and "difficult getting up from bed" (HR = 1.08, 95% CI: 1.05-1.10; P < 0.001). The corresponding population attributable risk percentage (PAR%) indicated that about 7% of healthspan termination in this cohort would have been eliminated if all participants had healthy sleep behaviors.

CONCLUSION: Participants who reported "usually experience sleeplessness/insomnia," "usually nap," "excessive daytime sleepiness," and "difficult getting up from bed" had increased risk of shortened healthspan. Therefore, adherence to healthy sleep behavior is significant for the extension of healthspan.

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Investigation of the relationships between sleep behaviors and risk of healthspan termination: a prospective cohort study based on 323,373 UK-Biobank participants

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