Sleep and Circadian Rhythm Abnormalities in the Pathophysiology of Bipolar Disorder

Bipolar disorder is associated with disturbances in sleep and biological rhythms that typically cycle over a 24-hour period.

• Circadian rhythm abnormalities may play a role in the symptoms of bipolar disorder, including mood, energy, and sleep variations.
• Evidence suggests that disruptions in circadian timing could contribute to the onset of bipolar episodes.
• Pharmacologic and psychosocial treatments targeting sleep and biological rhythms are being explored for their potential effects on bipolar symptoms.
• The chapter reviews known sleep and rhythm abnormalities linked to bipolar disorder and their implications for treatment.

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