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A systematic review and meta-analysis of sleep and circadian rhythms disturbances in individuals at high-risk of developing or with early onset of bipolar disorders
Sleep and daily rhythm problems in people at high risk for or with early bipolar disorder: a review and combined analysis
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Abstract
Pooled analyses indicate a 40% increased risk of bipolar disorder onset associated with pre-existing sleep and circadian rhythm disturbances.
- Self-ratings revealed a greater preference for eveningness among youth at risk for bipolar disorder and those with full-threshold bipolar disorder.
- Dysregulation of social rhythms was observed in both at-risk and full-threshold bipolar disorder groups.
- Actigraphy data provided some support for self-reported findings regarding circadian rhythm disturbances.
- Longer total sleep time was identified, particularly in offspring of parents with bipolar disorder and those with full-threshold bipolar disorder.
- Effect sizes in sleep disturbances were influenced by the proportion of participants showing psychopathology or using psychotropic medications.
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