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Polygenic risk scores for mood disorders and actigraphy estimates of sleep and circadian rhythms: A preliminary study in bipolar disorders
Genetic risk for mood disorders linked to sleep and daily rhythm patterns in bipolar disorder
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Abstract
In a sample of 62 euthymic individuals with bipolar disorder, a higher for major depressive disorder was associated with more fragmented sleep.
- Individuals with a higher polygenic risk score for major depressive disorder exhibited disrupted sleep patterns.
- A higher polygenic risk score for bipolar disorder correlated with a later peak in circadian rhythms of activity.
- These associations were significant even after adjusting for various factors such as age, sex, and current medications.
- Results were not significant after applying corrections for multiple comparisons.
- The findings suggest that genetic vulnerabilities to major depression and bipolar disorder may relate to distinct sleep and circadian rhythm abnormalities.
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Key numbers
0.29
Increase in Sleep Fragmentation
Spearman correlation coefficient for MDD (0.00005) with sleep fragmentation
0.36
Increase in Late Chronotype
Spearman correlation coefficient for BD (0.00005) with late chronotype