Metabolic syndrome and actigraphy measures of sleep and circadian rhythms in bipolar disorders during remission

May 31, 2018Acta psychiatrica Scandinavica

Metabolic syndrome linked to sleep and daily activity patterns in people with bipolar disorder during remission

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Abstract

Lower sleep efficiency is associated with higher triglyceride levels in patients with bipolar disorder.

Correlations exist between lower sleep efficiency and higher triglyceride levels (P = 0.002).
Lower M10 onset is linked to higher systolic blood pressure (P = 0.03).
Higher fragmentation index correlates with higher systolic blood pressure (P = 0.009).
Lower sleep efficiency and higher fragmentation index are associated with higher atherogenic index of plasma (P = 0.02 and P = 0.04, respectively).
Most correlations remained significant after adjusting for potential confounding factors.

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OBJECTIVE: This study explored the correlations between sleep and circadian rhythm measures and the metabolic syndrome (MetS) components in remitted patients with bipolar disorder (BD).

METHOD: Euthymic patients with BD (n = 67) were recorded by 3 weeks with actigraphy. We used nonparametric correlations to study the links between the MetS parameters, atherogenic index of plasma (AIP), sleep efficacy, sleep latency, fragmentation index, and phase and amplitude of rhythms. We performed multivariable analyses to take into account potential confounding factors such as sleep apnea risk, antipsychotics use, and smoker status.

RESULTS: We found correlations between lower sleep efficiency and higher triglyceride levels (P = 0.002), lower M10 onset (beginning of the 10 most active hours during the 24-h cycle) and higher systolic blood pressure (P = 0.03), higher fragmentation index and higher systolic blood pressure (P = 0.009), lower sleep efficiency, higher fragmentation index, and higher AIP (respectively P = 0.02 and P = 0.04). These correlations mostly remained significant when adjusting for confounders, with the exception of M10 onset and systolic blood pressure.

CONCLUSION: Sleep efficiency and fragmentation index might contribute to the cardiovascular risk of patients with BD independently of major confounding factors. Although these associations did not imply causality, proposing interventions on sleep quality and circadian rhythm regularity might contribute to reduce cardiovascular risk in patients with BD.

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Metabolic syndrome and actigraphy measures of sleep and circadian rhythms in bipolar disorders during remission

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