Genetic evidence suggested insomnia may increase the risk of endometriosis, while other sleep traits did not show causal associations.
Evidence
This bidirectional two-sample study found insomnia associated with endometriosis by inverse variance weighting (OR 2.021, 95% CI 1.280-3.192, P = .003) and tested multivariable adjustment for BMI, alcohol intake, smoking, and depression.
Caveat
Mendelian randomization depends on genetic-instrument assumptions and did not identify causal associations for chronotype, sleep duration, daytime napping, or daytime sleepiness.
Simplified
Evidence have indicated a correlation between sleep disorders and endometriosis, but the causal relationship remains uncertain. This study utilized (MR) approach to investigate the causal associations between sleep disorders and endometriosis. We conducted bidirectional 2-sample MR using inverse variance weighting as the primary analysis to assess forward and reverse causality. Multivariable Mendelian randomization were also utilized to adjust for confounders, reducing pleiotropy and residual confounding. Univariable MR analysis demonstrated a positive causal effect of insomnia on endometriosis (inverse variance weighting : 2.021, 95% confidence interval: 1.280-3.192, P = .003). Multivariable Mendelian randomization analysis further confirmed that the robustness of the causal association between insomnia and endometriosis after adjusting for key confounders, such as body mass index, alcohol intake, smoking, and depression. However, no causal associations were detected between endometriosis and other sleep-related traits, including chronotype, sleep duration, daytime napping, and daytime sleepiness. This MR study gave novel genetic evidence supporting insomnia as an independent risk factor for endometriosis. These findings highlight the need for greater attention to endometriosis-related sleep disorders in both clinical practice and medical research.
Key numbers
2.021
Increase in Endometriosis Risk
for insomnia's effect on endometriosis
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