Causal associations between sleep disorders and endometriosis: A Mendelian randomization analysis

Nov 8, 2025Medicine

Possible links between sleep problems and endometriosis from genetic analysis

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Abstract

Univariable analysis shows a positive causal effect of insomnia on endometriosis (: 2.021).

A bidirectional analysis using a approach was employed to explore causal relationships.
After adjusting for factors such as body mass index and depression, the causal link between insomnia and endometriosis remained robust.
No causal associations were found between endometriosis and other sleep-related traits like sleep duration or daytime sleepiness.
The study provides genetic evidence suggesting insomnia may act as an independent risk factor for endometriosis.

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Evidence have indicated a correlation between sleep disorders and endometriosis, but the causal relationship remains uncertain. This study utilized (MR) approach to investigate the causal associations between sleep disorders and endometriosis. We conducted bidirectional 2-sample MR using inverse variance weighting as the primary analysis to assess forward and reverse causality. Multivariable Mendelian randomization were also utilized to adjust for confounders, reducing pleiotropy and residual confounding. Univariable MR analysis demonstrated a positive causal effect of insomnia on endometriosis (inverse variance weighting : 2.021, 95% confidence interval: 1.280-3.192, P = .003). Multivariable Mendelian randomization analysis further confirmed that the robustness of the causal association between insomnia and endometriosis after adjusting for key confounders, such as body mass index, alcohol intake, smoking, and depression. However, no causal associations were detected between endometriosis and other sleep-related traits, including chronotype, sleep duration, daytime napping, and daytime sleepiness. This MR study gave novel genetic evidence supporting insomnia as an independent risk factor for endometriosis. These findings highlight the need for greater attention to endometriosis-related sleep disorders in both clinical practice and medical research.

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2.021

Increase in Endometriosis Risk

for insomnia's effect on endometriosis

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Causal associations between sleep disorders and endometriosis: A Mendelian randomization analysis

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