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Small-molecule modulators of the circadian clock: Pharmacological potentials in circadian-related diseases
Small molecules that adjust the body’s internal clock and their potential to treat clock-related diseases
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Abstract
Small-molecule modulators of the circadian clock (SMMCC) may influence various physiological effects by targeting core and noncore clock proteins.
- Disruption of circadian rhythms is associated with the development of clock-related diseases.
- SMMCCs can function as agonists, inverse agonists, or antagonists, affecting clock protein activity.
- The identification of SMMCCs has been aided by target-based screening and circadian crystallography.
- Established and novel SMMCCs may have therapeutic potential for treating a range of disorders, including metabolic, autoimmune, mood-related, and cancer-related conditions.
- Future considerations include the need for clinical trials and awareness of potential safety hazards.
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