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Social jetlag alters markers of exercise-induced mitochondrial adaptations in the heart
Social jetlag changes heart responses to exercise that affect energy production
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Abstract
Up to 70% of the population experiences (SJL), which disrupts circadian rhythms and may impact heart health.
- SJL resulted in significant shifts in physical activity timing during weekends for both sedentary and exercised mice.
- Exercise improved the speed of re-entrainment to the weekday schedule for mice under SJL conditions.
- Both control and SJL-exercised mice exhibited exercise-induced myocardial hypertrophy.
- SJL decreased expression of mitochondrial fusion proteins MFN1 and OPA1, while inhibiting exercise-induced increases in MFN2.
- These findings indicate that SJL disrupts the normal adaptations of heart muscle to exercise.
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Key numbers
15.28
Activity Onset Delay
Onset time for -SED mice on Weekend Day 1.
0.522
Mitochondrial Fusion Protein Expression
MFN2 expression in -EX compared to CON-EX.
0.003
Heart Mass Increase
Main effect of exercise on absolute heart mass.