Sodium‐glucose co‐transporter 2 inhibitors in addition to insulin therapy for management of type 2 diabetes mellitus: A meta‐analysis of randomized controlled trials

A meta-analysis of seven trials involving 4235 patients found that SGLT2 inhibitors with insulin therapy led to a mean reduction in HbA1c of -0.56%.

• SGLT2 inhibitor treatment was associated with a reduction in fasting plasma glucose by -0.95 mmol/L.
• Patients experienced a mean body weight reduction of -2.63 kg and a decrease in insulin dose by -8.79 IU.
• There was a 36% increased risk of drug-related adverse events, with urinary tract infections rising by 29% and genital infections by 357%.
• No significant increase was noted in overall adverse events, serious adverse events, adverse events leading to discontinuation, or hypoglycaemia events.
• No incidents of diabetic ketoacidosis were reported.

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