World journal of diabetes

How two diabetes drugs may help protect the kidneys beyond controlling blood sugar

Updated

Abstract

SGLT2 inhibitors have consistently and significantly reduced cardiovascular events, albuminuria, and glomerular filtration rate in patients with diabetic kidney disease.

  • Diabetic kidney disease is increasingly common as a complication of diabetes.
  • Traditional therapies have limited effectiveness in slowing progression to end-stage kidney disease.
  • SGLT2 inhibitors have transformed the treatment landscape for diabetic kidney disease and associated conditions.
  • GLP-1 receptor agonists show potential to slow renal disease progression and reduce albuminuria, despite fewer studies specifically on kidney disease.
  • Further research is needed to identify which patients will benefit most from these novel therapies.

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Funding

Competing interests

Conflict-of-interest statement: All authors declare no conflict of interest.
PubMed

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