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Solanum nigrum Polyphenol Extracts Inhibit Hepatic Inflammation, Oxidative Stress, and Lipogenesis in High-Fat-Diet-Treated Mice
Black Nightshade Plant Extracts Reduce Liver Inflammation, Oxidative Damage, and Fat Production in Mice on a High-Fat Diet
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Abstract
Solanum nigrum extracts (SNE) reduced blood triglyceride, sugar, and cholesterol levels in high-fat-diet-treated mice.
- SNE decreased fat accumulation, oxidative stress, and lipid peroxidation in mice with nonalcoholic fatty liver.
- The extract downregulated the expression of specific enzymes and proteins linked to fat metabolism through the AMPK pathway.
- SNE upregulated the expression of proteins that promote fat breakdown.
- A polyphenol extract from SNE reduced hepatic lipid accumulation.
- SNE may have potential as a health-food product to help prevent nonalcoholic fatty liver disease.
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