Somatostatin controls gut lining protein levels in mice with colitis

Somatostatin treatment significantly increased claudin-1 and claudin-3 expression in colitis mice models infected with Citrobacter rodentium.

• Alteration of tight junction proteins can lead to intestinal barrier damage and malabsorption of electrolytes and water.
• In colonic infection models, claudin-1 and claudin-3 expression decreased significantly compared to control mice.
• Octreotide treatment in CR infected mice resulted in a significant increase in claudin-1 and claudin-3 expression.
• In DSS colitis models, occludin and claudin-3 expression also decreased compared to control mice.
• Octreotide treatment in DSS colitis mice significantly upregulated claudin-3 expression.
• In vitro studies with Caco-2 cells exposed to E. coli and TNF-α supported the in vivo findings.

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