Loss of SREBF1 disrupts fat signaling and leads to slow muscle fiber breakdown

Loss of the SREBP1 gene in zebrafish led to disrupted slow-fiber organization and reduced muscle mass in adults.

• Srebp1 knockout resulted in increased locomotion in larvae.
• Altered fatty acid composition was observed in the knockout muscle.
• Arachidonoylethanolamide (AEA) levels were reduced, while palmitoylethanolamide (PEA) levels were elevated.
• Broad remodeling of polyunsaturated fatty acid-derived mediators occurred.
• Differential expression of genes related to cardiolipin metabolism was noted.
• The findings suggest SREBP1 plays a role in maintaining lipid balance and fiber type integrity, potentially influencing muscle degeneration.

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