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Stanniocalcin-1 promotes temozolomide resistance of glioblastoma through regulation of MGMT
Stanniocalcin-1 may increase resistance to temozolomide chemotherapy in brain tumors by controlling a DNA repair protein
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Abstract
High expression of (STC1) is associated with poor prognosis and chemotherapy resistance in glioblastoma.
- Tumour reproductive cells () demonstrate significantly higher viability when treated with temozolomide (TMZ) compared to standard two-dimensional cultures.
- RNA-seq analysis revealed upregulated expression of STC1 in TRCs cultured in three-dimensional soft fibrin gels.
- Clinical data indicate that high STC1 expression correlates with increased glioma grade and resistance to TMZ treatment.
- Overexpression of STC1 promotes DNA damage resistance in response to TMZ, while its knockdown inhibits this effect.
- STC1 is suggested to regulate MGMT expression in glioblastoma, highlighting its potential as a therapeutic target.
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Key numbers
40â50%
Increase in TMZ resistance
Tumor growth inhibition observed with knockdown and TMZ treatment.
422 patients
Correlation with poor prognosis
Analysis of clinical data from the CGGA database.