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Abstract
High expression of (STC1) is associated with poor prognosis and chemotherapy resistance in glioblastoma.
- Tumour reproductive cells () demonstrate significantly higher viability when treated with temozolomide (TMZ) compared to standard two-dimensional cultures.
- RNA-seq analysis revealed upregulated expression of STC1 in TRCs cultured in three-dimensional soft fibrin gels.
- Clinical data indicate that high STC1 expression correlates with increased glioma grade and resistance to TMZ treatment.
- Overexpression of STC1 promotes DNA damage resistance in response to TMZ, while its knockdown inhibits this effect.
- STC1 is suggested to regulate MGMT expression in glioblastoma, highlighting its potential as a therapeutic target.
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