Stress Granules Inhibit Apoptosis by Reducing Reactive Oxygen Species Production

Stress granules (SGs) are critical for controlling cell fate under stress conditions by regulating reactive oxygen species (ROS) levels.

• Cells can either undergo programmed cell death or repair themselves after environmental stress.
• SGs help prevent apoptosis by suppressing the rise of ROS, which can trigger cell death.
• G3BP1 and USP10 are key components of SGs that influence their antioxidant activity.
• G3BP1 inhibits USP10's antioxidant function, increasing steady-state ROS levels.
• After arsenite exposure, SG formation allows USP10 to exert its antioxidant effects.
• The antioxidant activity of USP10 is dependent on the protein kinase activity of ATM.

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