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Structural basis for psilocybin biosynthesis
Molecular structure behind how psilocybin is made
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Abstract
shows significant therapeutic potential for various psychiatric conditions.
- The study elucidates the crystal structures of key enzymes involved in psilocybin biosynthesis.
- Mechanisms of self-cleavage and self-inhibition in the enzyme PsiD are revealed.
- Sequential catalytic steps from 4-hydroxytryptamine to psilocybin are characterized.
- Biosynthetic intermediates of psilocybin demonstrate antidepressant properties in female mice with depression-like behaviors.
- The findings provide a structural basis for enhancing psilocybin production and highlight the potential of .
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Key numbers
significant decrease
Decrease in immobility time
Observed in forced swim test comparing treated vs. vehicle-injected SCVS mice.
significant increase
Increased social interaction time
Measured in social interaction tests among SCVS mice.