Computer modeling of a new remiketamine-like drug and related compounds: how they interact with NMDA receptors and a key metabolic enzyme

Short-acting ketamine-related scaffold design is an important medicinal-chemistry problem.

• Computational studies on ketamine scaffolds may provide insights into their potential effectiveness.
• Validation through receptor, enzymatic, and pharmacokinetic studies is necessary for accurate interpretation of findings.
• Current understanding of ketamine scaffold design is limited and requires cautious evaluation.

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