Journal of endocrinological investigation

Comparing the effects of injected GLP-1 drugs and SGLT2 inhibitors on metabolism and liver health in type 2 diabetes with fatty liver

Updated

Abstract

Subcutaneous GLP-1 receptor agonists (scGLP-1RA) may be more effective than SGLT2 inhibitors (SGLT2i) in managing metabolic dysfunction-associated steatotic liver disease (MASLD) in patients with type 2 diabetes mellitus (T2DM).

  • The study compares the effectiveness of two treatment options for MASLD in individuals with T2DM.
  • Genetic variants in GLP1R and PNPLA3 may influence how patients respond to the treatments.
  • The management of MASLD is complicated by its frequent coexistence with T2DM.

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Full Text

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Funding

Competing interests

No competing interests reported.
PubMed

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