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Ontogeny of sulfonylurea-binding regulatory subunits of KATP channels in the pregnant rat myometrium
Development of Sulfonylurea-Sensitive Regulatory Parts of Potassium Channels in Pregnant Rat Uterus Muscle
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Abstract
SUR1 levels in the pregnant rat myometrium increased markedly by day 6 of pregnancy before declining in later stages.
- SUR1 and SUR2 are subunits of ATP-sensitive potassium channels that may play a role in uterine contractility during pregnancy.
- SUR1 expression significantly rises during early pregnancy, peaking on day 6, while SUR2 levels remain stable throughout.
- Oxytocin-induced contractions can be inhibited by both diazoxide, which targets SURs non-selectively, and pinacidil, which selectively targets SUR2.
- The K(ATP) channel blocker glibenclamide counteracts the relaxing effects of both pinacidil and diazoxide.
- SURs are suggested to be key in the pharmacological response of K(ATP) channel openers in the myometrium.
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