The Suprachiasmatic Nucleus Entrains, But Does Not Sustain, Circadian Rhythmicity in the Olfactory Bulb

Jan 23, 2004The Journal of neuroscience : the official journal of the Society for Neuroscience

The brain’s main clock sets but does not keep daily rhythms in the smell-processing area

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Abstract

Constant lighting (LL) led to nearly 35% of rats losing behavioral rhythmicity after 2 weeks.

  • LL similarly affected locomotor, feeding behaviors, and Per1 expression in the suprachiasmatic nucleus (SCN).
  • LL lengthened the period of locomotor and SCN rhythms by approximately 1.6 hours.
  • 90% of rats that lost behavioral rhythmicity in LL showed no rhythm in Per1 expression in the SCN.
  • Returning rats to constant darkness rapidly restored daily cycles of running wheel activity and gene expression in the SCN.
  • The olfactory bulb (OB) maintained rhythmicity without significant period changes, even after prolonged behavioral arrhythmicity.
  • Lesions of the SCN abolished circadian rhythms in behavior but did not affect rhythms in the OB.

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