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Abstract
A new model may explain how ketamine provides lasting relief from depression symptoms after its effects wear off.
- Ketamine may prime synapses to enhance the effects of future doses.
- This review discusses a dosing strategy called primer pharmacology to optimize treatment outcomes.
- There is a potential link between ketamine's drug properties and its long-lasting effects on depression.
- The mechanisms activated by antidepressant treatments may overlap with those triggered by stress and therapy.
- Emerging treatments, like psychedelics, could offer new strategies for enhancing antidepressant effects.
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