JACC. Heart failure

How Common and Linked to Other Factors Is Body-Wide Inflammation in Heart Failure with Different Heart Pumping Levels

Updated

Abstract

Elevated high-sensitivity C-reactive protein (hsCRP) was found in 52.5% of patients with heart failure with preserved or mildly reduced ejection fraction.

  • Systemic inflammation, indicated by elevated hsCRP (≥2 mg/L), is prevalent in about half of heart failure patients.
  • Increased hsCRP levels are associated with being female, obesity, diabetes, lower kidney function, higher albuminuria, and chronic obstructive pulmonary disease.
  • No significant differences in hsCRP levels were observed based on heart failure subtype.
  • HsCRP levels did not correlate with ejection fraction but increased with the number of comorbidities across all heart failure types.

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Funding

Competing interests

Funding Support and Author Disclosures This study was funded by Novo Nordisk A/S. Dr Borlaug is supported by R01 HL128526, R01 HL162828, and U01 HL160226 from the National Heart, Lung, and Blood Institute, W81XWH2210245 from the United States Department of Defense, and the Schoen Foundation; has received research grant funding from AstraZeneca, Axon, GlaxoSmithKline, Medtronic, Mesoblast, Novo Nordisk, Rivus, and Tenax Therapeutics; has served as a consultant for Actelion, Amgen, Aria, Axon Therapies, BD, Boehringer Ingelheim, Cytokinetics, Edwards Lifesciences, Eli Lilly, Imbria, Janssen, Merck, Novo Nordisk, NGM, NXT, and VADovations; and is named inventor (US patent number 10,307,179) for the tools and approach for a minimally invasive pericardial modification procedure to treat heart failure. Drs Holse, Jung, and Stærk-Østergaard are employees of Novo Nordisk A/S. Dr Lincoff has received research funding from Esperion, Eli Lilly, AbbVie, CSL, AstraZeneca, and Novartis; and consulting fees from Novo Nordisk, Eli Lilly, Akebia, Alnylam, Amgen, Ardelyx, Becton-Dickson, Brainstorm Cell, Cadrenal, Endologix, FibroGen, GlaxoSmithKline, Intarcia, Medtronic, Neovasc, Provention Bio, and ReCor. Dr Mulvagh has received consulting fees from Novo Nordisk and Lantheus Medical Imaging. Dr Tuttle is supported by National Institutes of Health research grants R01MD014712, U2CDK114886, UL1TR002319, U54DK083912, U01DK100846, OT2HL161847, UM1AI109568, and OT2OD032581; is supported by CDC project numbers 75D301-21-P-12254 and 75D301-23-C-18264; has received investigator-initiated grant support from Travere, Bayer, and the Doris Duke Foundation outside the submitted work; has received consultancy fees from Boehringer Ingelheim, Eli Lilly, and Novo Nordisk; and has received speaker fees from Novo Nordisk. Dr Petrie has received research funding from Boehringer Ingelheim, Roche, SQ Innovations, AstraZeneca, Novartis, Novo Nordisk, Medtronic, Boston Scientific, and Pharmacosmos; and has consulted and/or served on committees for Abott, Akero, Applied Therapeutics, Amgen, AnaCardio, Biosensors, Boehringer Ingelheim, Corteria, Novartis, AstraZeneca, Novo Nordisk, AbbVie, Bayer, Horizon Therapeutics, Foundry, Takeda, Cardiorentis, Pharmacosmos, Siemens, Eli Lilly, Vifor, New Amsterdam, Moderna, Teikoku, LIB Therapeutics, 3R Lifesciences, Reprieve, FIRE 1, and Corvia.
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