Full text is available at the source.
What Causes DNA Damage in T Cells and What It Means
Updated
Abstract
T cells exhibit a substantial mutational burden due to DNA damage from various genotoxic stresses.
- Genotoxic stresses in T cells arise from rapid expansion in response to antigens and diverse nonlymphoid environments.
- There is a notable connection between genomic instability in T cells and the development of malignancies.
- Nonmalignant T cells show increased mutations associated with normal aging and various diseases.
- Autoimmune conditions and aging contribute to accelerated genomic damage in T cells.
- Intrinsic and extrinsic factors are implicated in the genotoxic stress experienced by T cells.
Simplified