A complete map of gene activity in human cell types

Tabula Sapiens 2.0 includes single-cell transcriptomic data from over two dozen organs and tissues, doubling the number of cells and adding four new tissues.

• Data from nine new donors contributes to a unique dataset controlling for genetic background, age, and epigenetic effects.
• The atlas encompasses transcripts from nearly all human transcription factors, suggesting potential cell-type specificity.
• Applications include insights into gene regulation and aging.
• Analysis of transcriptomes related to cellular senescence highlights the heterogeneity and context-dependent nature of this process.
• New hypotheses on senescence-associated pathways are proposed based on the findings.

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