Removing the Main Dog Allergen Gene to Reduce Allergies

Two genetically engineered beagle puppies were produced that lack the major dog allergen, Can f 1.

• Dog allergy is primarily caused by the allergen Can f 1 found in dog saliva.
• Genetic engineering techniques were used to create dogs without the Can f 1 protein.
• Analysis of the edited dogs confirmed no presence of Can f 1 in their saliva or fur.
• Skin prick tests showed that sensitized individuals reacted to normal dog extracts but not to those from the edited dogs.
• These findings indicate that removing the major allergen from dogs may effectively eliminate IgE-mediated allergic responses.

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