Tea polyphenol nano-crosslinked dynamical hyaluronic acid-based hydrogel for diabetic wound healing

The HP-TP@Ag hydrogel demonstrated significant wound healing effects in a diabetic mouse model, including accelerated wound closure and reduced inflammation.

• The hydrogel incorporates tea polyphenol-stabilized silver nanoparticles within a hyaluronic acid network, enhancing its biocompatibility and biodegradability.
• In vitro tests showed the hydrogel effectively scavenged reactive oxygen species, protecting cells from oxidative stress.
• The hydrogel suppressed pro-inflammatory cytokine production and exhibited strong antibacterial activity against E. coli and S. aureus.
• In vivo results indicated improved collagen deposition and promoted angiogenesis and tissue remodeling in treated wounds.
• The hydrogel exhibits glucose-responsive degradation and targeted release of nanoparticles within the diabetic wound microenvironment.

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